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Photo Description: High magnification (above) and low magnification (below) IHC image of the rat midbrain staining for tyrosine hydroxylase.

Adverse events were more common in patients being treated with pramipexole (73%) than with placebo (67%), the most common being nausea, headache, dizziness, and somnolence (drowsiness).

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The clinical picture in AADC is similar to that of tyrosine hydroxylase deficiency (TH), guanosine triphosphate cyclohydrolase (GTPCH) deficiency, sepiapterin reductase (SR) deficiency as well as other dopamine related diseases.

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Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy.

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It is evident from this review of switch studies that proposed conversion factors among the DAs have varied widely, underscoring the difficulty in determining a standardized conversion ratio and serving as a reminder that, on initiation of the new agent, a need for follow-up dose adjustments to account for variations in individual patient response is to be expected.

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Adding a drug called entacapone (Comtan) may prolong the duration of action of carbidopa-levodopa therapy (Sinemet), but it can cause nausea.

Augmentation differs from natural disease progression in that it is associated with pharmaceutical treatments and can cause extremely severe symptoms.

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